If you get hit by arms such as the first and second vaccines, you induce an immune response faster
Apr 29, 2025
|
According to a research team by Dr. Trippan of the Gavan Medical Research Institute in Sydney, Australia, and Anthony Callacher of the Kirby Institute at the University of New South Wales, published in the scientific journal Cell, mouse and human clinical trials have confirmed that the first and second doses of the vaccine on the same arm can induce a faster and more effective immune response.
The research team, which previously discovered that memory B cells, which play a key role in antibody responses during reinfection, remain in the lymph nodes closest to the injection site for a long time, said it has identified the reason and impact.
When vaccinated using state-of-the-art in vivo imaging technology in mouse experiments, we found that memory B cells move to the layer outside the nearest lymph node and interact with the macrophages there. It was also found that additional inoculations at the same location efficiently capture antigens and activate memory B cells to induce antibody formation reactions to occur quickly and strongly.
In order to confirm whether this result also applies to human vaccines, 30 volunteers were vaccinated with the COVID-19 mRNA vaccine, while 20 were given the first and second doses on the same arm and 10 were injected on the other side. The results showed that participants who received the first and additional doses on the same arm produced neutralizing antibodies against the COVID-19 virus (SARS-CoV-2) significantly faster than those who received the other arm within the first week after the additional dose.
The research team pointed out that the antibody levels of the two groups became similar four weeks after the second dose, but the initial protection effect in the first week of inoculation can be very important during the epidemic of infectious diseases.
This article was translated by Naver AI translator.
