Muscle after losing weight?Weight loss injections likely to increase the risk of osteoporosis and fractures

Jun 05, 2025

Muscle after losing weight?Weight loss injections likely to increase the risk of osteoporosis and fractures
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Experts have warned that weight loss injections can cause muscle and bone mass loss, increasing the risk of osteoporosis and fractures.

According to foreign media such as the Daily Mail, the Royal Society for Osteoporosis (ROS) said in a recent study that up to 40% of weight lost using GLP-1 agents comes from muscle and bone mass.

Reducing muscles reduces the strength and joint stability of the body, and lowering bone density increases the risk of osteoporosis. Osteoporosis is a disease that can be easily fractured due to weak bones.




Currently, GLP-1 injections are known to have a weight loss effect of up to 20%. However, experts stress that the negative effects of using the drug must be recognized.

In an interview with local media outlet Sunday Express, an official from the British Academy of Osteoporosis said, `Although research in the field is still ongoing, we must warn that the use of GLP-1 injections poses a high risk of bone and muscle loss as well as body fat" he insisted.

He added that "Bone and muscle health are key factors in prevention of falls and fractures, and fractures can lead to premature death or severely degrade independent living abilities."




In addition, he emphasized that GLP-1 injections must be properly prescribed, requiring sufficient consultation with a doctor.

In particular, women may have a greater risk of osteoporosis as their bone density rapidly decreases due to decreased estrogen after menopause.

Professor Carl Heneghan of the University of Oxford in the United Kingdom warned that "drugs that reduce muscle mass and bone density are highly inappropriate for vulnerable patients at high risk of fracture.'




"The longer GLP-1 injections are taken, the greater the risk," he said. "Resolving the obesity problem should focus on prevention, not the way to make the entire population dependent on drugs." he insisted.

A recent analysis by Liverpool University in the UK also confirmed that up to 40% of the weight lost through GLP-1 agents was lost in muscle and bone mass.

Dr Taher Mahmood of the London Osteoporosis Clinic says "People taking GLP-1 injections must be aware of the importance of proper nutrition and weight-bearing exercise," he stressed.



This article was translated by Naver AI translator.