Donguibogam Palmultang-based additive prescription proves its effectiveness in restoring immunity
Jul 14, 2025
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Palmultang is a traditional prescription consisting of eight herbal medicines, and it is a herbal medicine prescription that supplements blood pressure and strengthens immune function. It has been widely used to improve fatigue and weakness caused by anemia, chronic diseases, post-morbid weakness, and immune decline, and recently, various prescriptions have been made for adding or subtracting medicinal ingredients depending on the purpose of use.
Dr. Hong Jin-young's research team at Jaseng Oriental Hospital's Spinal Joint Research Institute used Gampal Multang, which consists of a total of 14 medicinal herbs including angelica, ginseng, licorice, and bokryeong, in this study. The research team used a mouse model with decreased immune function by administering cyclophosphamide (CPA), an immunosuppressant, and conducted oral administration experiments for 14 days on four groups: ▲ normal group ▲ CPA administration group (immunosuppression group) ▲ PMT 100mg/kg administration group ▲ PMT 200mg/kg administration group.
First of all, it was confirmed that the expression of the cytokine IL-10 (Interleukin-10), an anti-inflammatory immune protein that regulates immune balance and suppresses inflammation, was significantly increased in proportion to the PMT dose through experimental mouse cell experiments.
In particular, in the 200mg/kg administration group, the IL-10 level was about three times higher than that of the immunosuppressed group, showing a strong immune recovery effect. In addition, as a result of blood tests, white blood cells (WBC) and eosinophil (EOS) levels, which were reduced by CPA administration, are also recovering, proving that Gampalmultang contributes to the improvement of overall immune function.
In addition, it showed a clear effect in terms of immune cell activation. In the sweet potato soup-administered group, CD4+ and CD8+ T lymphocyte counts, which are major components of T cells involved in immune function, were significantly increased. CD4+ is a 'help T cell' that coordinates the immune response, and CD8+ is a 'cytotoxic T cell' that eliminates virus-infected cells, each playing a key role in the immune system. In particular, in the case of the PMT 200 mg/kg administration group, CD4+ cells increased about 1.5 times and CD8+ cells increased about 1.4 times compared to the immunosuppressive group. In addition, the atrophic size and tissue structure of the thymus, an organ where immune cells mature, also recovered to normal levels.
In addition, recovery was also observed in the proportion of CD25+ cells, an immunomodulatory indicator. CD25+ plays an important role in maintaining T cell activity and immune balance, and as a result of flow cytometry (FACS), the proportion of CD25+ cells dropped sharply from about 25% in the normal group to about 13% in the CPA-treated group. On the other hand, in the PMT 100mg/kg and 200mg/kg groups, it improved significantly in proportion to the dose, up to 17.1% and 20.4%, respectively.
Dr. Hong Jin-young of the Spinal Joint Research Institute at Jaseng Oriental Medicine Hospital, said "This study has scientifically confirmed that the traditional prescription Palmultang can be an effective complementary treatment for restoring immunity."In the future, we will continue to reveal the possibility of oriental medicine as a natural-based treatment through more extensive research."."
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This article was translated by Naver AI translator.
