AI-Based Quality Microbiome Analysis, Diagnostic Paradigm Shift
Aug 29, 2025
The results of an international joint study on the high objectivity and accuracy 'Vaginal Microbiome Analysis' in women's health examinations have been published, drawing keen attention.
Professor Park Seon-hwa of obstetrics and gynecology at Ewha Womans University Mokdong Hospital published her latest review paper on the 7th in the journal Frontiers in Cellular and Infection Microbiology' in the field of life science.
This paper was proposed by the British Medicines and Healthcare products Regulatory Agency (MHRA), and was conducted in collaboration with King's College Hospital in London and Liverpool University.
To date, women's health diagnoses have relied on diagnostic tools that lack objectivity and accuracy. The research team confirmed that next-generation sequencing (NGS), metabolome analysis, and vaginal microbiome analysis using AI-based algorithms can change the paradigm of diagnosis.
According to the results of the study, the imbalance of Lactobacillus, a major beneficial bacterium in the vagina, and the increase in harmful bacteria were closely related to ▲ bacterial vaginitis ▲ sexually transmitted infection ▲ premature acid ▲ endometriosis ▲ cervical cancer ▲ pulmonary disease. In response, the paper emphasized that women's health can be fundamentally improved if a system that can diagnose and treat changes in the microbiome early is applied in clinical practice. In particular, microbiome-based analysis is expected to exceed the limitations of existing diagnostic techniques as non-invasive and precise diagnosis is possible.
In particular, this international joint study is significant in that Park Soon-hee, CEO of BioWave W, a company in open laboratories at Ewha Womans University Mok-dong Hospital, participated together to present a successful joint research model between hospitals and medical device companies.
BioWave W, which develops microbiome in vitro diagnostic medical devices for early preterm diagnosis, is the only company in Korea to participate in the WHO international standard construction project in the microbiome field, and has recently prepared intestinal microbiome DNA standards that are suitable for international standards and suitable for Koreans.
Park Soon-hee, CEO of BioWave W, said "The microbiome field was difficult to secure reliability due to severe data deviations and was not standardized. In the meantime, international standards for WHO intestinal microbiome DNA have been established under the leadership of the UK, which is expected to greatly help research and development in the future""BioWave W will make efforts to improve women's health through efficient cooperation with Professor Kim Young-joo and Professor Park Sun-hwa's team at Ewha Womans University Mokdong Hospital in research and development of diagnostic and preventive drugs related to the vaginal microbiome.""
Professor Sun-Hwa Park of Obstetrics and Gynecology at Ewha Womans University Mokdong Hospital, who participated as the lead author of the preterm birth and pregnancy complications part in this paper, said "We frequently witness cases where women's reproductive health is threatened by inaccurate diagnosis in the clinical field. The vaginal microbiome analysis predicts that early diagnosis and precise intervention can play a major role in areas where early diagnosis and precision intervention are key, such as preterm birth and infertility, and applying these diagnostic techniques will be of practical help to women's health."
Meanwhile, in a recent study, Professor Park Sun-hwa developed a machine learning model that predicts the risk of premature birth based on the vaginal microbiome and discovered a biomarker that can be applied clinically by combining multiple omics information. Currently, it is working with BioWave W to develop a multi-gene amplification in vitro diagnostic medical device for testing harmful bacteria related to vaginal microbiome imbalance (Dysbiosis).
Professor Park Seon-hwa of obstetrics and gynecology at Ewha Womans University Mokdong Hospital published her latest review paper on the 7th in the journal Frontiers in Cellular and Infection Microbiology' in the field of life science.
This paper was proposed by the British Medicines and Healthcare products Regulatory Agency (MHRA), and was conducted in collaboration with King's College Hospital in London and Liverpool University.
To date, women's health diagnoses have relied on diagnostic tools that lack objectivity and accuracy. The research team confirmed that next-generation sequencing (NGS), metabolome analysis, and vaginal microbiome analysis using AI-based algorithms can change the paradigm of diagnosis.
According to the results of the study, the imbalance of Lactobacillus, a major beneficial bacterium in the vagina, and the increase in harmful bacteria were closely related to ▲ bacterial vaginitis ▲ sexually transmitted infection ▲ premature acid ▲ endometriosis ▲ cervical cancer ▲ pulmonary disease. In response, the paper emphasized that women's health can be fundamentally improved if a system that can diagnose and treat changes in the microbiome early is applied in clinical practice. In particular, microbiome-based analysis is expected to exceed the limitations of existing diagnostic techniques as non-invasive and precise diagnosis is possible.
In particular, this international joint study is significant in that Park Soon-hee, CEO of BioWave W, a company in open laboratories at Ewha Womans University Mok-dong Hospital, participated together to present a successful joint research model between hospitals and medical device companies.
BioWave W, which develops microbiome in vitro diagnostic medical devices for early preterm diagnosis, is the only company in Korea to participate in the WHO international standard construction project in the microbiome field, and has recently prepared intestinal microbiome DNA standards that are suitable for international standards and suitable for Koreans.
Park Soon-hee, CEO of BioWave W, said "The microbiome field was difficult to secure reliability due to severe data deviations and was not standardized. In the meantime, international standards for WHO intestinal microbiome DNA have been established under the leadership of the UK, which is expected to greatly help research and development in the future""BioWave W will make efforts to improve women's health through efficient cooperation with Professor Kim Young-joo and Professor Park Sun-hwa's team at Ewha Womans University Mokdong Hospital in research and development of diagnostic and preventive drugs related to the vaginal microbiome.""
Professor Sun-Hwa Park of Obstetrics and Gynecology at Ewha Womans University Mokdong Hospital, who participated as the lead author of the preterm birth and pregnancy complications part in this paper, said "We frequently witness cases where women's reproductive health is threatened by inaccurate diagnosis in the clinical field. The vaginal microbiome analysis predicts that early diagnosis and precise intervention can play a major role in areas where early diagnosis and precision intervention are key, such as preterm birth and infertility, and applying these diagnostic techniques will be of practical help to women's health."
Meanwhile, in a recent study, Professor Park Sun-hwa developed a machine learning model that predicts the risk of premature birth based on the vaginal microbiome and discovered a biomarker that can be applied clinically by combining multiple omics information. Currently, it is working with BioWave W to develop a multi-gene amplification in vitro diagnostic medical device for testing harmful bacteria related to vaginal microbiome imbalance (Dysbiosis).
|
This article was translated by Naver AI translator.
