I thought it was mouth inflammation and stomatitis...Rare disease Becchett disease signal?

Apr 15, 2025

I thought it was mouth inflammation and stomatitis...Rare disease Becchett disease signal?
photo courtesy of Korea University Medical Center



#. Ms. Oh, a female worker in her 30s, is in charge of the project at the company and is tired from excessive work and extreme stress. Persistently recurrent mouth loose and tingling ulcers appeared for several months. Oh thought it was simple stomatitis, purchased antibiotics at a pharmacy, took them, and applied ointment, but the symptoms did not improve easily. In the end, it wasn't until the ulcer spread all over his mouth and he couldn't eat properly that Oh visited the hospital and was diagnosed with 'Betchett's disease.

Betchett's disease is a typical autoimmune disease, and major symptoms include loose mouth, ulcers around genitals, skin lesions, and inflammation of the eyes (glucitis). These symptoms appear simultaneously or in stages over several years, and when a wound occurs, it is an inflammatory disease of unknown cause that lasts longer than a healthy person.

Bechet's disease is a type of vasculitis that causes inflammation of blood vessels, so it can cause inflammation not only on the skin but also anywhere the blood vessels pass. Although it starts with a wide variety of symptoms, oral ulcers are usually the first to occur. In 70% of patients with oral ulcers, nodular erythema or folliculitis accompanied by tenderness on the skin of the leg, along with vulva ulcers, are repeated.




When vulva inflammation occurs, urinary and reproductive functions may be impaired, inflammation and ulceration of the intestines including the large intestine may cause diarrhea or bloody excrement, and brain aneurysm may be accompanied, but rupture of an aneurysm may have dangerous consequences. When Betchett's disease occurs in the eyes, it causes uveitis, which can lead to blindness in serious cases, and arthritis can also occur due to invasion of joints.

Betchett's disease is classified as a rare and intractable disease with a prevalence of less than 20,000 people in Korea, and it occurs more in the East than in the West. Although the exact cause is not yet known, it is believed that abnormalities in the immune system are caused by genetic predisposition and environmental factors.

The diagnosis of Becchett's disease is based on various symptoms and signs. The diagnosis is based on comprehensive judgment through eye inflammation, including visible oral ulcers, genital ulcers, characteristic skin lesions, and checking for hyper-sensitive reactions. In the test for Bethett's disease, a blood test is a test to determine the degree of inflammation or complications, and it is difficult to diagnose Bethett's disease by blood test alone.




Most immune diseases are intractable diseases that are difficult to treat as the cause is unclear. Betchett's disease is also an incurable disease, but it is by no means an incurable disease. It can occur regardless of gender or age, and you cannot let your guard down just because you are young. In order to prevent Betchett's disease, it is recommended to rest through sufficient sleep and eat nutritious food that helps improve immunity. In addition, it is important to thoroughly manage overwork and stress so that there is no disturbance in the immune system.

Lee Young-ho, a professor of rheumatology at Korea University Anam Hospital, said "Continuous management and constant observation are essential in the event of an outbreak because it is not a disease that continuously worsens, but a disease that repeats the improvement and relaxation of the condition."Above all, conditioning is essential because it tends to worsen after fatigue or overwork, and if symptoms suspected of Becchett's disease, especially repeated oral ulcers, do not heal easily and persist and recur, you should quickly visit a hospital for an accurate diagnosis.

I thought it was mouth inflammation and stomatitis...Rare disease Becchett disease signal?
이영호 교수





This article was translated by Naver AI translator.