Next-generation EGF of kimchi-derived probiotics proves the effect of improving blemishes and wrinkles...Checking the possibility of cosmetic ingredients
Sep 08, 2025
Epithelial cell growth factor (EGF) is known to be effective in skin regeneration, wrinkle improvement, and pigmentation relief, and is widely used in the domestic and foreign cosmetics industry. However, due to the nature of protein raw materials, they are easily affected by pH, temperature, and enzymes, so there is a limit to securing stability and delivery efficiency, so a new technical approach to overcome this has been required.
Professor Park Gui-young of the dermatology department at Chung-Ang University Hospital and a joint research team at Cell BioTec Co., Ltd. developed a 'next-generation EGF (postbiotic EGF)' that genetically improves the probiotic Pediococcus pentosaceus CBTSL4 isolated from kimchi, allowing this strain to secrete EGF proteins during growth.
The research team manufactured them in the form of culture supernatant (PP-EGF-SUP) and freeze-dried powder (PP-EGF-DP), and conducted protein analysis and function verification. As a result of conducting a four-week human body application test on 20 adult women in Korea, it was confirmed that the test group using 1% and 5% PP-EGF-DP ampoules reduced the blemish lesions on the face by 21.2% and 29.1%, respectively. No skin adverse reactions were reported during the trial period.
Ahn Byung-chul, Ph.D. at Cell Biotech's R&D Center, said, "PP-EGF does not only provide EGF protein, but also works together with metabolites produced by probiotics, which can be expected to provide additional skin protection effects such as antioxidants, anti-inflammatory, and antibacterial."This is a strength that differentiates it from existing EGF raw materials" he said.
Professor Park Gui-young of the dermatology department at Chung-Ang University Hospital, the corresponding author, said "This study is an example that shows that by combining microorganism-based biotechnology and protein-active factors, all stability, safety, and multifunctionality can be secured."It is expected to open a new paradigm for the development of cosmetic raw materials in the future."
The results of this study were published in the SCIE international journal Cosmetics and are expected to be used as important basic data for functional cosmetics research and industrial applications in the future.
Professor Park Gui-young of the dermatology department at Chung-Ang University Hospital and a joint research team at Cell BioTec Co., Ltd. developed a 'next-generation EGF (postbiotic EGF)' that genetically improves the probiotic Pediococcus pentosaceus CBTSL4 isolated from kimchi, allowing this strain to secrete EGF proteins during growth.
The research team manufactured them in the form of culture supernatant (PP-EGF-SUP) and freeze-dried powder (PP-EGF-DP), and conducted protein analysis and function verification. As a result of conducting a four-week human body application test on 20 adult women in Korea, it was confirmed that the test group using 1% and 5% PP-EGF-DP ampoules reduced the blemish lesions on the face by 21.2% and 29.1%, respectively. No skin adverse reactions were reported during the trial period.
Ahn Byung-chul, Ph.D. at Cell Biotech's R&D Center, said, "PP-EGF does not only provide EGF protein, but also works together with metabolites produced by probiotics, which can be expected to provide additional skin protection effects such as antioxidants, anti-inflammatory, and antibacterial."This is a strength that differentiates it from existing EGF raw materials" he said.
Professor Park Gui-young of the dermatology department at Chung-Ang University Hospital, the corresponding author, said "This study is an example that shows that by combining microorganism-based biotechnology and protein-active factors, all stability, safety, and multifunctionality can be secured."It is expected to open a new paradigm for the development of cosmetic raw materials in the future."
The results of this study were published in the SCIE international journal Cosmetics and are expected to be used as important basic data for functional cosmetics research and industrial applications in the future.
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This article was translated by Naver AI translator.
