Netrin1 Suggests Possible Treatment of Vascular Dementia...Professor Lee Min-woo's team at Hallim University Sacred Heart Hospital selected excellent new research projects
Mar 26, 2025
A research team led by Professor Lee Min-woo of the Department of Neurology at Hallym University Sacred Heart Hospital (Professor Lee Min-woo of Neurology and Professor Ahn Eun-hee of the Department of Medicine and Physiology at Hallym University) was recently selected for the 'New Project for Excellent Advanced Research in 2025' organized by the Ministry of Science and ICT and the Korea Research Foundation.
The name of this research project is 'Examination of the neuroprotective mechanisms and the role of Netrin-1 as a diagnostic biomarker in vascularized cognitively impaired patients and animal models'. The research team will receive a total of 650 million won in research funds for three years starting this year with the aim of proving the effectiveness of vascular dementia and Netrin-1 protein molecules and developing treatments.
Vascular dementia is a disease in which cognitive function is deteriorated due to brain cell damage. It is a serious disease that accounts for 20-40% of all dementia cases, and is the second most common type of dementia after Alzheimer's disease. In particular, according to a recent neuropathological study, vascular pathology and Alzheimer's pathology were found simultaneously in 40% of dementia patients who died, highlighting the importance of a multifaceted approach. Accordingly, Professor Lee Min-woo's research team wants to expand the base of dementia research by upgrading the classification of dementia models from the clinical stage of vascular mechanisms.
Professor Lee Min-woo conducted basic research on the Korea Research Foundation for two years from 2022 to build a foundation for intermediary research on cerebrovascular diseases, and is currently developing a primary model for vascular cognitive decline. Professor Lee plans to analyze the significant correlation between the vascular dementia model and Netrin-1 by linking basic research and clinical research with Professor Ahn Eun-hee of Hallym University's physiology class, and verify its applicability as a treatment.
Netrin is a protein responsible for guiding nerve cells. Among them, Netrin-1 has shown great effects in preventing degenerative cognitive decline including Alzheimer's dementia through ▲ strengthening cell connection ▲ promoting cerebrovascular regeneration ▲ controlling neuroinflammation.
Professor Lee Min-woo said, "Through this study, we will establish a vascular cognitive decline cohort for patients complaining of cognitive decline due to cerebrovascular disease, identify the association between specific Netrin molecules and vascular cognitive decline, suggest new research directions, and contribute to improving the quality of life of patients."
Meanwhile, Professor Lee Min-woo has abundant clinical experience related to the field of vascular cognitive decline and the prognosis of acute stroke, and has published 23 SCIE papers related to cerebrovascular disease (IF total 137 points) as the main or corresponding author from 2022 to the present. In addition, it received the Academic Non-Research Expense and Academic Research Support Award at the Korean Academy of Hypertension and the Korean Dementia Association in 2023 for research on vascular cognitive decline, and simultaneously won the Paul Dudley White International Scholar Award and the Junior Investigator Award at the International Stroke Conference (ICSU).
The name of this research project is 'Examination of the neuroprotective mechanisms and the role of Netrin-1 as a diagnostic biomarker in vascularized cognitively impaired patients and animal models'. The research team will receive a total of 650 million won in research funds for three years starting this year with the aim of proving the effectiveness of vascular dementia and Netrin-1 protein molecules and developing treatments.
Vascular dementia is a disease in which cognitive function is deteriorated due to brain cell damage. It is a serious disease that accounts for 20-40% of all dementia cases, and is the second most common type of dementia after Alzheimer's disease. In particular, according to a recent neuropathological study, vascular pathology and Alzheimer's pathology were found simultaneously in 40% of dementia patients who died, highlighting the importance of a multifaceted approach. Accordingly, Professor Lee Min-woo's research team wants to expand the base of dementia research by upgrading the classification of dementia models from the clinical stage of vascular mechanisms.
Professor Lee Min-woo conducted basic research on the Korea Research Foundation for two years from 2022 to build a foundation for intermediary research on cerebrovascular diseases, and is currently developing a primary model for vascular cognitive decline. Professor Lee plans to analyze the significant correlation between the vascular dementia model and Netrin-1 by linking basic research and clinical research with Professor Ahn Eun-hee of Hallym University's physiology class, and verify its applicability as a treatment.
Netrin is a protein responsible for guiding nerve cells. Among them, Netrin-1 has shown great effects in preventing degenerative cognitive decline including Alzheimer's dementia through ▲ strengthening cell connection ▲ promoting cerebrovascular regeneration ▲ controlling neuroinflammation.
Professor Lee Min-woo said, "Through this study, we will establish a vascular cognitive decline cohort for patients complaining of cognitive decline due to cerebrovascular disease, identify the association between specific Netrin molecules and vascular cognitive decline, suggest new research directions, and contribute to improving the quality of life of patients."
Meanwhile, Professor Lee Min-woo has abundant clinical experience related to the field of vascular cognitive decline and the prognosis of acute stroke, and has published 23 SCIE papers related to cerebrovascular disease (IF total 137 points) as the main or corresponding author from 2022 to the present. In addition, it received the Academic Non-Research Expense and Academic Research Support Award at the Korean Academy of Hypertension and the Korean Dementia Association in 2023 for research on vascular cognitive decline, and simultaneously won the Paul Dudley White International Scholar Award and the Junior Investigator Award at the International Stroke Conference (ICSU).
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This article was translated by Naver AI translator.
