Autonomic nervous system abnormalities associated with cognitive decline in early Parkinson's disease
Jul 24, 2025
Research has shown that autonomic nerve dysfunction in early Parkinson's disease patients is closely related to cognitive decline.
In particular, among various autonomic neurological dysfunction, gastrointestinal dysfunction was found to be more closely related to cognitive decline in patients with early Parkinson's disease. Parkinson's disease is a complex disease accompanied by not only motor dysfunction but also various non-motor symptoms such as cognitive decline, sleep disturbance, and autonomic nervous system abnormalities.
The research team at Soonchunhyang University Seoul Hospital (first author Joo Byung-eok, corresponding author Kwon Gyeom-il) included this in a paper published in the international journal 『Scientific Reports" in May on the association between cognitive and autonomic neurological disorders in new Parkinson's disease patients".
Professor Kwon Gyeom-il and Joo Byung-eok's team analyzed the clinical records of 82 new Parkinson's disease patients registered in the Parkinson's Disease Register at Soonchunhyang University Seoul Hospital.
The research team divided 21 patients with mild cognitive impairment into 61 patients, and compared various autonomic neurological dysfunction scores using the Autonomic Nervous System Function Assessment Scale (SCOPA-AUT).
The study found that Parkinson's disease patients with cognitive impairment had more than five times more autonomic neurological dysfunction scores and four times more gastrointestinal disorders than those who did not. This means that overall autonomic nervous system abnormalities, including gastrointestinal dysfunction, are deeply associated with cognitive decline in the early stages of Parkinson's disease.
In addition, the worse the autonomic nerve function, the worse the memory and concentration. The higher the autonomic nerve dysfunction score, the lower the memory test score, and the lower the concentration and judgment. In other words, autonomic nerve dysfunction can be directly linked to decreased brain memory beyond body discomfort.
Professor Kwon Gyeom-il confirmed that there is a significant association between autonomic neurological dysfunction and cognitive decline in neonatal Parkinson's disease""Identifying autonomic neurological dysfunction may help predict cognitive decline diagnosis in early Parkinson's disease patients."."
Professor Joo Byung-eok said, `This study is a retrospective study conducted on a relatively small number of patients, and although generalization requires attention, it is meaningful that various autonomic nerve functions were evaluated using the autonomic nervous system function evaluation scale in early Parkinson's disease patients.'
In particular, among various autonomic neurological dysfunction, gastrointestinal dysfunction was found to be more closely related to cognitive decline in patients with early Parkinson's disease. Parkinson's disease is a complex disease accompanied by not only motor dysfunction but also various non-motor symptoms such as cognitive decline, sleep disturbance, and autonomic nervous system abnormalities.
The research team at Soonchunhyang University Seoul Hospital (first author Joo Byung-eok, corresponding author Kwon Gyeom-il) included this in a paper published in the international journal 『Scientific Reports" in May on the association between cognitive and autonomic neurological disorders in new Parkinson's disease patients".
Professor Kwon Gyeom-il and Joo Byung-eok's team analyzed the clinical records of 82 new Parkinson's disease patients registered in the Parkinson's Disease Register at Soonchunhyang University Seoul Hospital.
The research team divided 21 patients with mild cognitive impairment into 61 patients, and compared various autonomic neurological dysfunction scores using the Autonomic Nervous System Function Assessment Scale (SCOPA-AUT).
The study found that Parkinson's disease patients with cognitive impairment had more than five times more autonomic neurological dysfunction scores and four times more gastrointestinal disorders than those who did not. This means that overall autonomic nervous system abnormalities, including gastrointestinal dysfunction, are deeply associated with cognitive decline in the early stages of Parkinson's disease.
In addition, the worse the autonomic nerve function, the worse the memory and concentration. The higher the autonomic nerve dysfunction score, the lower the memory test score, and the lower the concentration and judgment. In other words, autonomic nerve dysfunction can be directly linked to decreased brain memory beyond body discomfort.
Professor Kwon Gyeom-il confirmed that there is a significant association between autonomic neurological dysfunction and cognitive decline in neonatal Parkinson's disease""Identifying autonomic neurological dysfunction may help predict cognitive decline diagnosis in early Parkinson's disease patients."."
Professor Joo Byung-eok said, `This study is a retrospective study conducted on a relatively small number of patients, and although generalization requires attention, it is meaningful that various autonomic nerve functions were evaluated using the autonomic nervous system function evaluation scale in early Parkinson's disease patients.'
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This article was translated by Naver AI translator.
