Young Patients with cerebral infarction Have 1.84 Times Risk of Dementia When Diabetes Lasts For More Than 5 Years
Apr 29, 2025
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The research team, including Professor Lee Min-woo of the Department of Neurology at Hallym University Sacred Heart Hospital, Professor Lee Jae-joon of the Department of Anesthesiology and Pain Medicine at Hallym University Chuncheon Sacred Heart Hospital, Professor Chun Dae-young of Circulatory Medicine at Dongtan Sacred Heart Hospital at Hallym University, and Professor Han Kyung-do of the Department of Information Statistics Insurance and Mathematics at Soongsil University, revealed the correlation between the risk of dementia according to the duration of type 2 diabetes.
Type 2 diabetes is a metabolic disease in which insulin is normally secreted from the pancreas, but the ability to lower blood sugar is poor. Unlike type 1 diabetes, which naturally has problems with insulin secretion itself, type 2 diabetes is mainly caused by lifestyle factors such as poor eating habits or lack of exercise in adulthood.
The research team followed 118,790 people with cerebral infarction within five years using data from men and women aged 40 or older registered with the National Health Insurance Service in 2009 for seven years and three months. The subjects were divided into group 1 aged 40 to 64 and group 2 aged 65 or older according to age, and diabetes status was classified into a total of 5 types: ▲ normal ▲ fasting blood glucose disorder ▲ new onset ▲ less than 5 years ▲ more than 5 years of onset.
As a result of the study, the longer the duration of type 2 diabetes, the higher the incidence of dementia by up to 1.5 times. A simple comparison of the incidence of dementia was found to be 17.7% (1.16 times) in new cases of type 2 diabetes, 18.9% (1.24 times) in less than five years of development, and 23.0% (1.5 times) in more than five years of development. Even considering risk factors that can affect dementia, patients who have suffered from diabetes for more than five years were found to have a 46.7% higher risk of developing dementia.
In addition, the longer the duration of type 2 diabetes in group 1 (40-64 years old), which is a relatively young age group, the higher the incidence of dementia. The incidence of dementia in group 1 was 4.5% normal, 4.3% for fasting blood glucose disorder, 4.9% for new cases of type 2 diabetes, 6.3% for less than 5 years of onset, and 9.3% for more than 5 years of onset. If type 2 diabetes lasted for more than 5 years, the risk was 1.84 times higher compared to normal even after controlling several variables. On the other hand, the increase in the risk of developing dementia was relatively small in Group 2 (65 years of age or older).
The research team emphasized the need for early intervention to prevent dementia in the case of long-term diabetes among cerebral infarction patients. The longer the diabetes prevalence period, the higher the risk of dementia, so a preventive approach to blood sugar control and cognitive function is important.
Professor Lee Min-woo "This study confirmed that patients with cerebral infarction have a significant increased risk of developing dementia according to the duration of type 2 diabetes before the disease develops."It is important to prevent type 2 diabetes from being prolonged, especially in the younger age group " he said.
Professor Lee explained that if type 2 diabetes begins at a young age, cerebrovascular damage accumulates for a long time, and dementia is more likely to occur after a stroke. "If cerebral infarction occurs in the brain condition that has been vulnerable to diabetes for a long time, secondary nerve damage and inflammatory reactions can be accelerated, increasing the risk of dementia."
The study was published in the March issue of the SCIE-level international journal "Alzheimer's Research & Therapy" under the title of "Diabetes Status, Duration, and Risk of Dementia in Patients with cerebral infarction."
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This article was translated by Naver AI translator.
