Immunization imbalance due to inflammatory response cell activation...Patients with multiple sclerosis and optic nerve myelitis, probability of other autoimmune diseases ↑
May 26, 2025
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In the recent issue of the "Mayo Clinic Proceedings", Min Ju-hong, a professor of neurology at Samsung Medical Center, Shin Dong-wook, a professor of family medicine, Kwon Soon-wook, a professor of neurology at Inha University Hospital, and a research team at Soongsil University in Hankyung-do are the results of the research.
Based on data from the National Health Insurance Service between 2010 and 2017, the research team followed 1987 patients with multiple sclerosis and 2,071 patients with optic sclerosis category disease from a year after diagnosis, and patients with multiple sclerosis were newly diagnosed with other autoimmune diseases within 4.5 years and 4.3 years on average.
First of all, patients with multiple sclerosis had a 17.2 times higher risk of being diagnosed with Bethett's disease. Patients with optic scleritis category disease had an 82.6-fold increased risk of developing Sjogren syndrome and a 30.8-fold increased risk of developing systemic lupus erythematosus.
The research team estimates that this is due to the common characteristics of the development and progression of autoimmune diseases. Analysts say that instead of cells that normally control immunity, cells that cause inflammatory reactions are activated, and immune imbalances in which inflammatory substances are secreted have occurred, resulting in another autoimmune disease.
An autoimmune disease is a disease in which the body's immune system attacks the body. Multiple sclerosis and optic nerve myelitis category diseases can occur anywhere in the central nervous system, such as the optic nerve, brain, and spinal cord, and are accompanied by various symptoms such as visual impairment, one sensory and motor disorders, and dizziness. Optical spinal cord ulcers occur in the optic nerve and spinal cord rather than the brain, resulting in loss of vision and paralysis of the lower extremities.
Professor Min Ju-hong "We should prepare for the fact that other autoimmune diseases may develop even after diagnosis of multiple sclerosis and optic nerve myelitis category disease."When treating patients, a long-term management strategy should be established with the possibility of developing related diseases in mind."
This article was translated by Naver AI translator.
