Cinnamon-derived ingredients, possible treatment for dementia...Effect on improving cognitive function
Sep 23, 2025
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This could be a turning point in the treatment of Alzheimer's disease, the researchers explained.
Taiwanese researchers published the results of a study on the efficacy of sodium benzoate produced by metabolizing cinnamon in the body through the international journal Translational Psychiatry.
Sodium benzoate (or sodium benzoate) is a preservative used in various fields such as food, medicine, and cosmetics. It mainly serves to prevent spoilage by inhibiting the growth of mold and bacteria in acidic foods, and is used as a preservative and lubricant in pharmaceuticals and as a coolant corrosion inhibitor in industrial use.
It is said that excessive consumption of sodium benzoate can cause irritation of the eyes or mucous membranes and allergic dermatitis.
The clinical study involved 149 patients with mild Alzheimer's between the ages of 50 and 100.
All of them had high blood amyloid-beta levels and cognitive decline was observed. The researchers divided the participants into four groups to take placebo, 500mg, 750mg, and 1000mg of sodium benzoate daily, respectively.
As a result of the 24-week experiment, cognitive function was significantly improved in the 750mg and 1000mg groups, especially in patients with higher blood amyloid-beta 42 levels. On the other hand, these changes were not seen in the group taking the placebo. Sodium benzoate showed a similar level to placebo in terms of safety and tolerability, and it was confirmed that there was little concern about side effects.
"Sodium benzoate has potential as a novel treatment to reduce amyloid-beta, which is known to be a major cause of Alzheimer's disease," the researchers said.
In particular, it is attracting attention in that it can be taken orally, unlike conventional expensive intravenous treatments.
However, the researchers say that the study period is only 24 weeks, and there is a limit to generalization because it is conducted only for Taiwanese"We need more long-term research and global analysis in the future."
Prior to this, there have been studies suggesting the association between cinnamon components and Alzheimer's improvement effects.
In 2016, Dr. Calipada Farhan of Rush University in the United States published a study showing that cinnamon can help treat Parkinson's disease by suppressing its progression.
In addition, a joint Chinese-Brazilian researcher reported in 2023 that sodium benzoate inhibits the accumulation of tau protein entangled in neurons as well as amyloid-beta.
This article was translated by Naver AI translator.
