Daewoong Pharmaceutical's fat-destroying injection VOLET is effective on forearms Domestic research team announces SCIE journal
May 19, 2025
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According to Daewoong Pharmaceutical, a research team led by Prof. Park Gwi-young at Chung-Ang University Hospital and Dr. Yoon Chun-sik at Yemi-won Dermatology Department of Dermatology has been published in the SCIE-level journal 『Journal of Cosmetic Dermatology』 in the United States.
Deoxycholic acid, the main component of Daewoong Pharmaceutical's first fat-destroying injection VOLET, launched in 2021, is a mechanism that reduces the number by destroying fat cells, and unlike other lipolytic agents that reduce the size of fat cells, it can be expected to have a semi-permanent effect and helps maintain and improve skin elasticity with an action mechanism that induces collagen synthesis.
This study was the first case to confirm the fat reduction effect when deoxycholic acid, which was mainly used for under-the-jaw procedures, was applied to the forearm (the back of the upper arm) through clinical trials in Koreans, demonstrating the possibility of using VOLET in forearm fat procedures.
According to the study, VOLET 5 mg/mL and 2.5 mg/mL were treated three times over 8 weeks in the forearm area and observed for 20 weeks, and the thickness of subcutaneous fat decreased by an average of 7.49 mm and 4.68 mm, respectively. The length of the upper arm circumference was also confirmed to decrease by 1.55 mm and 1.1 mm on average at 20 weeks after administration.
A method of diluting deoxycholic acid was also presented. The research team used sterile physiological saline to adjust VOLET injections to 5mg/mL (1:1 dilution) and 2.5mg/mL (1:3 dilution), respectively, and administered them to the forearm area. As a result, the visual analog scale (VAS) score, which quantified the pain felt by the patient, averaged 5.7 points and 2.3 points, respectively, and the lower the concentration, the less pain the patient tended to suffer.
Professor Park Gui-young evaluated that "This is the first study to apply Violet to the upper arm rather than the chin, and it is of great clinical significance in that it has analyzed the effect of reducing subcutaneous fat and pain response according to various treatment concentrations.".
This article was translated by Naver AI translator.
