Gastric cancer can also be inherited?...Asia's First Link to Lynch Syndrome Proof
May 13, 2025
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Lynch syndrome is a genetic cancer syndrome in which a specific condition called 'micropathic instability (MSI-H)' occurs as a mutation in a gene that functions as DNA repair. It is known to increase the risk of developing colorectal cancer and uterine cancer. However, the association between Korean gastric cancer patients with high gastric cancer incidence and Lynch syndrome has not been systematically studied.
In response, a joint surgical research team at Soonchunhyang University Bucheon Hospital and Cheonan Hospital (Professors Choi Yoon-young, Yoon Jong-hyuk, Lee Won-jong, and Lee Moon-soo) selected 127 patients (8.3%) who were identified as 'non-incident instability' out of 1,537 patients who underwent gastric cancer surgery at Soonchunhyang University Bucheon Hospital and Cheonan Hospital from 2011 to 2023, and conducted a Whole Exome Sequencing (WES) on 123 patients with normal tissues. As a result, it was confirmed that about 5% of patients had 'Lynch syndrome'.
Professor Choi Yoon-young of Soonchunhyang University Bucheon Hospital said "This study is the first large-scale study in Asia to prove the link between Lynch syndrome and brown subcapsular unstable gastric cancer. This suggests that genetic factors should also be considered when treating gastric cancer patients, and that genetic testing and family history evaluation are necessary."
"In the future, we will continue research on genetic gastric cancer based on precision medical care, including early diagnosis of gastric cancer through genetic testing and prevention strategies such as Helicobacter eradication for patient families..." he said.
The study was published in the latest issue of the world-renowned cancer journal 'Chinese Journal of Cancer Research (IF: 7.0)' and was recognized for its academic value by winning the 'Best Investigator Award' at the International Conference of the Korean Society of Surgeons (ACKSS 2024). In the future, when diagnosing and treating gastric cancer, it is expected to be an important turning point in the prevention of cancer and the realization of customized precision medical care not only for individual patients but also for the entire family.
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This article was translated by Naver AI translator.
