Promoting fibrosis such as fine dust and damage to kidney tubules and glomeruli in newborns...Vitamin D Partial Improvement
May 26, 2025
A study found that fine dust damages the tubules and glomeruli of fetal and newborn kidneys and tends to promote kidney fibrosis in the long term.
In addition, vitamin D supplementation has the effect of partially improving such damage, suggesting that vitamin D intake can play an important role as a preventive treatment for kidney damage caused by environmental pollution.
Son Min-hwa, director of Uijeongbu Strong Children's Hospital, started the study to track the effects of fine dust (PM2.5) on kidney development in fetuses and newborns and to analyze the potential protective effects of vitamin D supplementation on kidney damage caused by fine dust.
This study investigated the effects of exposure to particulate matter during pregnancy and after childbirth causing tubular atrophy, glomerular damage, and increased collagen deposition in the kidneys of male mice and confirmed a significant increase in inflammatory response and fibrosis markers in renal tissue.
It also analyzed the protective effect that vitamin D inhibits the expression of fibrosis-related genes such as TGF-β1, fibronectin, and α-SMA and exhibits anti-inflammatory effects.
Director Son Min-hwa said, "This study is of great significance in that it identified the interaction between environmental hazards and nutritional interventions and presented practical intervention strategies for the health of pregnant women and newborns. We will continue to present disease prevention-oriented treatment directions through convergence research on environmental health and preventive nutrition for children."," he said.
Meanwhile, the study was published in the May 2025 issue of the journal Current Issues in Molecular Biology, a prestigious biology journal as the SCI journal.
In addition, vitamin D supplementation has the effect of partially improving such damage, suggesting that vitamin D intake can play an important role as a preventive treatment for kidney damage caused by environmental pollution.
Son Min-hwa, director of Uijeongbu Strong Children's Hospital, started the study to track the effects of fine dust (PM2.5) on kidney development in fetuses and newborns and to analyze the potential protective effects of vitamin D supplementation on kidney damage caused by fine dust.
This study investigated the effects of exposure to particulate matter during pregnancy and after childbirth causing tubular atrophy, glomerular damage, and increased collagen deposition in the kidneys of male mice and confirmed a significant increase in inflammatory response and fibrosis markers in renal tissue.
It also analyzed the protective effect that vitamin D inhibits the expression of fibrosis-related genes such as TGF-β1, fibronectin, and α-SMA and exhibits anti-inflammatory effects.
Director Son Min-hwa said, "This study is of great significance in that it identified the interaction between environmental hazards and nutritional interventions and presented practical intervention strategies for the health of pregnant women and newborns. We will continue to present disease prevention-oriented treatment directions through convergence research on environmental health and preventive nutrition for children."," he said.
Meanwhile, the study was published in the May 2025 issue of the journal Current Issues in Molecular Biology, a prestigious biology journal as the SCI journal.
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This article was translated by Naver AI translator.
