Multi-Gene Score Of Cognitive Preliminary Ability Affects On The Speed Of Parkinson's Disease Progress
Aug 20, 2025
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Cognitive reserve refers to the brain's ability to resist cognitive decline when there is a neurodegenerative change in the brain and can be estimated through education level, job achievement, intelligence level, and brain volume. In addition, the multi-genetic score is a score that estimates an individual's genetic predisposition or vulnerability to a specific trait or disease outbreak, and the genetic effect of alleles can be calculated through statistical methods using a number of genetic variations with a genome-wide association study.
Recently, as large-scale WGS correlation analysis studies have become active, multi-genetic scores on cognitive reserve are being used to predict the risk of development and disease progression in various diseases.
Using genomic information from 851 Parkinson's disease patients on the AMP PD (Accelerating Medicine Partnership® Parkinson's Disease) database, the research team analyzed whether there is a time difference between the ▲ Hoenya scale of 3 points or more (based on deterioration of motor function) ▲ Montreal Cognitive Assessment of 24 points or less (based on dementia) ▲ MDS-UPDRS hallucinations and mental symptoms score of 1 point or more (based on psychosymptomatic symptoms).
As a result of Cox regression analysis, Parkinson's disease patients with high multi-genetic scores on education levels decreased the risk of worsening motor symptoms by 19.6% per unit increase, and the risk of dementia decreased by 45.2% per unit increase. It was also confirmed that the risk of hallucinations and delusions in Parkinson's disease patients with high multi-genetic scores for job achievement decreased by 21.7% per unit increase.
Professor Heo Young-eun's team analyzed the association between the multi-genetic score on education level, job achievement, and intelligence level and Parkinson's disease's motor deterioration, dementia occurrence, and mental symptoms (perception, forgetfulness) and found that the multi-genetic score on cognitive reserve ability could be used as a biomarker to predict the progression of Parkinson's disease.
Professor Heo Young-eun said, "Parkinson's disease is a disease that has no treatment to fundamentally prevent the development and progression of the disease. It is important to select patients who are expected to progress quickly and improve appropriate medical treatment and lifestyle and environmental factors before symptoms worsen.".
The study was conducted in collaboration with Professor Won Hong-hee of Sungkyunkwan University's Samsung Convergence Medical School (SHIST) and Professor Raj of the Icahn School of Medicine at Mount Sinai (New York) in the United States.
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This article was translated by Naver AI translator.
