Preoperative blood and CT information can predict the risk of recurrence of gallbladder cancer

Aug 12, 2025

Preoperative blood and CT information can predict the risk of recurrence of gallbladder cancer
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Nomogram (prediction model) has been developed that can predict early recurrence of gallbladder cancer only with blood and CT information before surgery.

It is a model that predicts the risk of recurrence within a year after surgery, and if widely used in clinical settings in the future, it is expected to contribute to improving the prognosis of patients with gallbladder cancer.

Yoon So-kyung, a research team led by a professor of surgery at Soonchunhyang University Seoul Hospital, published in the international cancer journal 『Cancers" in April, and developed and external verification of the prediction nomogram for early recurrence of gallbladder cancer using prognostic factors available before surgery : Development and External Validation of a Nomogram Predicting Early Recurrence of a Gallbladder Cancer Using Preoperatively Available Progressive Studies}' The paper contains this information.




Professor Yoon So-kyung's team analyzed preoperative prognostic factors related to early recurrence of gallbladder cancer in 251 patients who underwent resection for the purpose of curing gallbladder cancer from 2008 to 2017.

The preoperative prognostic factors used in the nomogram are ▲ gender (male) ▲ chronic liver disease ▲ preoperative symptoms ▲ elevated levels of cancer antigens ▲ sarcopenic obesity ▲ clinical T3 abnormal stage ▲ suspected lymph node metastasis. Among the indicators, chronic liver disease and elevated CEA levels can be confirmed by blood tests, and muscle-reducing obesity, clinical T3 abnormal stage, and suspected lymph node metastasis can be confirmed by CT image information.

In order to verify the clinical effectiveness and practical applicability of the developed nomogram, the research team also verified the prediction accuracy of 176 patients from Soonchunhyang University Seoul Hospital, Soonchunhyang University Bucheon Hospital, and Kyungpook National University Chilgok Hospital. As a result of the verification, Nomogram showed a strong predictive power of about 87.2% in internal verification and about 70.3% in external verification, indicating that it can be applied in clinical settings.




Professor So-kyung Yoon explained, `The newly developed nomogram for predicting early recurrence of gallbladder cancer is of great significance in that it has laid the foundation for patient-specific treatment, such as predicting the risk of recurrence of patients before surgery, providing preemptive and enhanced treatment strategies for high-risk patients, and reducing the burden of unnecessary invasive treatment for low-risk patients.'

On the other hand, gallbladder cancer occurs relatively rarely in Korea, but it is classified as incurable cancer due to its poor prognosis due to its high recurrence rate even after diagnosis or high recurrence rate after surgery. Since early recurrence, especially within 1 year of surgery, has a devastating effect on the long-term survival rate of patients, it is of paramount importance to predict the risk of recurrence before surgery and to establish customized treatment strategies.



Preoperative blood and CT information can predict the risk of recurrence of gallbladder cancer
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This article was translated by Naver AI translator.