The guaranteed number of bacteria is guaranteed until you put it in your mouth...It's not like the actual survival rate of the gut
Sep 03, 2025
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Cell Biotech, which develops the lactobacillus brand 「DUOLAC」, discloses a related infographic and refers to the number of lactobacilli guaranteed until it is put in the mouth, and is a completely different concept from the number of lactobacilli that actually passes through the digestive system and reaches the intestine. Many consumers immediately interpret the guaranteed number of bacteria as intestinal survival rates, but this is a misunderstanding.
According to Cell Biotech, lactobacillus enter the human body and are exposed to digestive fluids such as strong stomach acid (pH2) and bile acid, and most of them die. Gastric acid is a major defense mechanism that removes external pathogens and kills beneficial and harmful bacteria. For this reason, lactobacilli that live to the intestines are only a small part of the intake.
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Coating technology that protects lactic acid bacteria has been developed for generations. The first generation of ▲ were exposed to stomach acid and bile as they were with noncoating lactobacilli (Nude-LAB) and mostly died before reaching the intestine. The ▲2nd generation enteric coating LAB was designed to disintegrate only in the intestine, but it was difficult to control the disintegration timing and had limitations in capsule formulation. Micro-encapsulated LAB, which is currently widely used by many companies due to its high production efficiency, greatly increased stability by wrapping lactobacillus with coating materials, but there was a limitation that the coating had to be completely melted for activation.
Cell Biotech developed the world's first ▲ 4th generation dual matrix coating LAB, which protects lactic acid bacteria from the human environment such as stomach acid and bile acid and delivers them safely to the intestine by double coating live lactic acid bacteria with protein and polysaccharides. It is a structure in which a solid coating is maintained in the stomach, the coating is naturally unwound in the intestine, and lactobacillus is activated by using the difference in acidity (pH) unique to the human body. "Currently, it has secured patents in five countries, including Korea, Japan, China, the United States, and Europe, proving its global technological prowess." he said. Accelerated stability, acid resistance, and bile resistance experiments confirmed a maximum lactobacillus survival rate of 91.6%, and human application tests conducted in collaboration with Samyuk Medical Center showed that the intestinal survival rate was up to 221 times higher than that of non-coated lactobacilli.
A Cell Biotech official said "Many consumers choose products based on the number of lactobacilli guaranteed bacteria, but the actual health effects depend on the technology that lives to the intestines and reaches them. I hope that the infographic will help spread the importance of correct information delivery and coating technology."
This article was translated by Naver AI translator.
